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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are often characterized by a focus on the practical aspects of research design, like the recruitment process and consent as well as adherence to the use of routinely available equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which used different investigators and participants from different geographical regions. This type of heterogeneity, which is vital for a pragmatic trial to be valid and to reduce bias in the results, is also necessary. However, too much heterogeneity can result in problems with the design of the trial.

Pragmatic Play Pragmatic Play, a major player on the live casino market, offers various classic table games, including Blackjack and Roulette. The live studios of Pragmatic Play in Romania and Malta offer customers an authentic experience in gambling as well as a broad variety of betting options via virtual. The company also has several game shows which make online gambling enjoyable and engaging. Some of these shows feature a live host, while others are hosted by prominent personalities from the industry.

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In addition to their mobile-friendly slot machines, Pragmatic Play also offers table games and live dealer casinos. Pragmatic Play is licensed by various regulatory bodies, including Malta Gaming Authority and UK Gambling Commission. The games are protected by the latest encryption technology and the security team is available to assist players solve any issues they might have.

Pragmatic Play's slot games are popular with newbies as well as experienced players. They have modern graphics and traditional themes. They have a variety of paylines and bonus rounds and many offer progressive jackpots. They are not volatile, which means you can enjoy a long gaming experience.

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Legality

Pragmatic Play has earned a reputation for providing top-notch games and an exceptional user experience. The software is available on mobile devices and in multiple languages. Despite its relative youth, it has already established itself as a leading casino gaming platform. Wolves is one of the latest games that is a 5-reel slot machine with a healthy RTP and impressive graphics. The other notable titles include Wolf Gold and Chilli Heat.

Pragmatic trials are designed to replicate real-life situations and attain maximum external validity. They are usually commissioned by policy makers and practitioners to inform their decision making. They can also be a great method of determining the cause-effect relationship between the intervention and its effects. However, they should not be used in lieu for explanatory studies.

The pragmatism idea is controversial and there are concerns about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested an distinction between explanation-based studies, which confirm the validity of a physiological or clinical hypothesis, as well as pragmatic trials, that inform the practice and policy decision-making. They also suggested a framework known as PRECIS for pragmatic trials.2 The tool was designed to define the characteristics of a pragmatic study, including recruitment, design, implementation of the intervention and follow-up.

There is a positive trend in the number of pragmatic trials that are published. A recent Medline query that used the words naturalistic and pragmatic, restricted to randomised controlled trials (RCTs) returned 34 articles. They are displayed in red on Figure 2. This is an indication that the health science community is becoming increasingly sensitized to the issue of pragmatic thinking. It is important to note that the majority of these trials were conducted in primary care settings.