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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are often characterized by a focus on the practical aspects of the research design, 프라그마틱 슬롯체험 like recruitment and consent in adherence, as well as the use of routinely available equipment.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which utilized different investigators and participants from various geographical areas. This type of heterogeneity, which is vital for a pragmatic trial to be valid and reduce bias in results is also essential. However, too much heterogeneity could cause issues with the trial design.

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The purpose of pragmatic trials is to replicate real-life scenarios and to achieve maximum credibility externally. They are usually commissioned by policy makers and practitioners to aid in their decision-making. They can also be a great method of determining the causal relationship between an intervention and its outcomes. However, they should not be used to substitute for explanatory trials.

The idea of pragmatism is controversial, and there are questions about whether pragmatic trials should replace explanatory tests or if they are an addition to them. Schwartz and Lellouch1 proposed a distinction between explanatory studies, which prove a physiological hypothesis or clinical hypothesis, and pragmatic trials, which inform the practice and policy decision-making. They also proposed a framework called PRECIS for pragmatic trials.2 This tool tried to define the traits of a pragmatic research study that includes recruitment, design, implementation of the intervention and its follow-up.

The number of pragmatic trials is increasing. A recent Medline query using the keywords pragmatic and naturalistic, limited to randomised controlled trials (RCTs) returned 34 articles. These are shown in red on Figure 2. This is an indication that the health science community is becoming more sensitive to the issue of pragmatic thinking. It is important to remember that the majority of these trials were conducted in primary care settings.