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Clinical trials that are designed to help inform practice in the real world are known as pragmatic trials. They are often focused on practical aspects of the study design, such as the recruitment process and consent as well as adherence to the use of commonly available equipment.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which employed various investigators and 프라그마틱 슬롯체험 플레이 - teslanews.lv - participants from different geographic areas. This type of heterogeneity is essential for practical trials to be valid and helps reduce the chance of bias in the results. Too much heterogeneity, however can result in problems with the trial design.

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The purpose of pragmatic trials is to simulate real-life scenarios and gain maximum credibility externally. Usually, they are requested by practitioners and policymakers to help guide their decisions. They can be used to determine the causal relationship between an intervention and its results. However, they should not be used in lieu for explanation trials.

The concept of pragmatism is controversial, and there are doubts about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 made a distinction between explanatory studies, which confirm a physiological hypothesis or clinical hypothesis, and pragmatic trials that aid in policy and practice decision-making. They also suggested a framework dubbed PRECIS for pragmatic trials.2 The tool was designed to define the characteristics of a pragmatic study that includes the recruitment, design, and delivery of the intervention, and follow-up.

There is an encouraging trend in the number of pragmatic trials published. A recent Medline search using the words pragmatic and naturalistic, 프라그마틱 슬롯 사이트 limited to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This is an indication that the health sciences community is becoming more acquaint to the subject of pragmatism. It is important to keep in mind that the majority of these studies were conducted in primary care settings.